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Diet disease in modification renal -

21-12-2016 à 10:40:25
Diet disease in modification renal
Abstract Background Observational cohort studies and a secondary prevention trial have shown an inverse association between adherence to the Mediterranean diet and cardiovascular risk. The two Mediterranean-diet groups had good adherence to the intervention, according to self-reported intake and biomarker analyses. All participants provided written informed consent. Methods In a multicenter trial in Spain, we randomly assigned participants who were at high cardiovascular risk, but with no cardiovascular disease at enrollment, to one of three diets: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat). Beginning on October 1, 2003, participants were randomly assigned, in a 1:1:1 ratio, to one of three dietary intervention groups: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with nuts, or a control diet. Participants received quarterly individual and group educational sessions and, depending on group assignment, free provision of extra-virgin olive oil, mixed nuts, or small nonfood gifts. Full Text of Methods. None of the sponsors had any role in the trial design, data analysis, or reporting of the results. A primary end-point event occurred in 288 participants. We conducted a randomized trial of this diet pattern for the primary prevention of cardiovascular events. Detailed enrollment criteria are provided in the Supplementary Appendix, available at NEJM. Methods In a multicenter trial in Spain, we randomly assigned participants who were at high cardiovascular risk, but with no cardiovascular disease at enrollment, to one of three diets: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat). Abstract Background Observational cohort studies and a secondary prevention trial have shown an inverse association between adherence to the Mediterranean diet and cardiovascular risk. On the basis of the results of an interim analysis, the trial was stopped after a median follow-up of 4. Full Text of Methods. 8 years. We conducted a randomized trial of this diet pattern for the primary prevention of cardiovascular events.


The two Mediterranean-diet groups had good adherence to the intervention, according to self-reported intake and biomarker analyses. 10-12 The trial was designed and conducted by the authors, and the protocol was approved by the institutional review boards at all study locations. org. On the basis of the results of an interim analysis, the trial was stopped after a median follow-up of 4. 8 years. 10-12 The trial was designed and conducted by the authors, and the protocol was approved by the institutional review boards at all study locations. A primary end-point event occurred in 288 participants. None of the sponsors had any role in the trial design, data analysis, or reporting of the results. The primary end point was the rate of major cardiovascular events (myocardial infarction, stroke, or death from cardiovascular causes). The primary end point was the rate of major cardiovascular events (myocardial infarction, stroke, or death from cardiovascular causes). Detailed enrollment criteria are provided in the Supplementary Appendix, available at NEJM. org. Participants received quarterly individual and group educational sessions and, depending on group assignment, free provision of extra-virgin olive oil, mixed nuts, or small nonfood gifts. All participants provided written informed consent. Details of the trial design are provided elsewhere. Beginning on October 1, 2003, participants were randomly assigned, in a 1:1:1 ratio, to one of three dietary intervention groups: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with nuts, or a control diet. Details of the trial design are provided elsewhere.

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